歡迎來到上海通蔚！

021-54845833/15800441009

品質保證 · 通蔚試劑

當前位置: 首頁 > 科研產品 > 科研抗體 > 其他抗體 > ALKBH8抗原（重組蛋白）

產品中心

  • ALKBH8抗原（重組蛋白）

    規(guī)格：
    數(shù)量：

    購買數(shù)量

    價格：￥
    • 品牌 : 通蔚生物
    • 目錄號 : TW16047
    • 應用 : 僅限于科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存：60
  • 商品詳情
  • 參考文獻
  • 說明書下載
  • 商品評論0
  • 相關產品

中文名稱： ALKBH8抗原（重組蛋白）

英文名稱： ALKBH8 Antigen (Recombinant Protein)

別     名： ABH8; TRM9; TRMT9

儲     存： 冷凍（-20℃）

相關類別： 抗原

概     述

Full length fusion protein

技術規(guī)格

Full name:

alkB homolog 8, tRNA methyltransferase

Synonyms:

ABH8; TRM9; TRMT9

Swissprot:

Q96BT7

Gene Accession:

BC015183

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

ALKBH8 (alkylated DNA repair protein AlkB homolog 8) is a 664 amino acid protein that is encoded by a gene located on chromosome 11. ALKBH8 contains one RRM (RNA recognition motif) domain and belongs to the AlkB family of proteins. ALKBH8 is one of many homologs of the Escherichia coli protein AlkB. AlkB functions to protect DNA and RNA against damage from environmental methylating compounds by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzyme acts by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate and molecular oxygen as the oxidizing agent. Three isoforms exist for ALKBH8 due alternative splicing of the gene.